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Cellnomica is a global leader in the area of software to support systems biology. Our focus is on modeling and simulation of multicellular systems such as tissue, organs and organisms. This gives insights that single cell modeling and simulation cannot achieve. For example, insights may be gained into multicellular diseases such as cancer. Furthermore, scientists can test hypotheses about the regulation of developing organisms. They can observe the effects of changing the genome on the dynamics of the developing organism.

What is systems biology?

Computational systems biology is concerned with developing mathematical and computational models in order to simulate in software (in silico) biological systems and to study their properties. The area has seen a rapid growth of interests by scientists, researchers, pharmaceutical companies and research institutions. The systems modeled and simulated include gene transcription, RNA translation, cellular pathways, intra-cellular networks, cellular communication, cell signaling, signal transduction pathways and networks, transcriptional activation, gene regulation, genomic networks, protein networks, whole cell simulation, cell growth, cell division, multicellular development, organ dynamics and development. The reason modeling and simulation are so important is that the complexity of biological systems makes it practically impossible to understand the structure and dynamics of such systems. It is only with the help of software simulations that one can gain insight into biological systems.

• Werner, E. "Bioinformatics and Systems Biology: An Overview" (PDF)
  This is an extended version of Dr. Eric Werner's article published in New Drugs Magazine March 2002

Economic Reports Including Cellnomica

• Cambridge Health Institute Report
  Allan B. Ha berman, Ph.D., "Biochemical Pathway and Systems Analysis for Target Identification and Validation", Cambridge Healthtech Institute Report Evaluates Advances in Uncovering New Drug Targets. (CHI Report )
  
• Frost and Sullivan Report
  Report D238-0, Bioinformatics: Players; Problems; and Processes in Computational Biology, Published: 08/08/2002 (Frost Report)
  
  

Journal Articles Including Cellnomica

• Werner, E., "The Future and Limits of Systems Biology", Science STKE 2005, pe16 (2005).(Abstract)
• Werner, E., "Genome Semantics, In Silico Multicellular Systems and the Central Dogma", FEBS Letters 579, pp 1779-1782 (March 21, 2005).(Abstract)
• Constans, Ileen, "Desk Top Drug Discovery"(Pdf), The Scientist, Vol. 18, Issue 4, March 2004.
• Werner, E., "In silico multicellular systems biology and minimal genomes", DDT vol 8, no 24, pp 1121-1127, Dec 2003.(Abstract)
• Jackson R.C., "Predictive Software for Drug Design and Development: Recent Progress and Future Developments", Pharmaceutical Development and Regulation, vol. 1, no. 3, pp. 159-168(10), 2003. Abstract
• Diane Gershon "Biology gets plugged in", Nature 417, 27 June 2002, 6 (2002)
• Werner, E., "In silico cell signaling underground", Science STKE,(170):PE8., Feb 18, 2003.
• Werner, E., "Systems biology unplugged", DDT, forthcoming, Spring 2003.
• Werner, E., "Systems biology: the new darling of drug discovery?", DDT Vol. 7, No. 18, September 2002.
• Werner, E., "Bioinformatics and Systems Biology: An Overview" NewDrugs Magazine , Issue 3, March 2002.

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