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Multicellular Systems Biology

Cellnomica is a global leader in the area of software to support systems biology. Our focus is on modeling and simulation of multicellular systems such as tissue, organs and organisms. This gives insights that single cell modeling and simulation cannot achieve. For example, insights may be gained into multicellular diseases such as cancer. Furthermore, scientists can test out hypotheses about the regulation of developing organisms. They can observe the effects of changing the genome on the dynamics of the developing organism.

 

What is systems biology?

Computational systems biology is concerned with developing mathematical and computational models in order to simulate in software (in silico) biological systems and to study their properties. The area has seen a rapid growth of interests by scientists, researchers, pharmaceutical companies and research institutions. The systems modeled and simulated include gene transcription, RNA translation, cellular pathways, intra-cellular networks, cellular communication, cell signaling, signal transduction pathways and networks, transcriptional activation, gene regulation, genomic networks, protein networks, whole cell simulation, cell growth, cell division, multicellular development, organ dynamics and development. The reason modeling and simulation are so important is that the complexity of biological systems makes it practically impossible to understand the structure and dynamics of such systems. It is only with the help of software simulations that one can gain insight into biological systems.

For an overview of systems biology see:

Werner, E. "Bioinformatics and Systems Biology: An Overview" (PDF)